2025 NCAA Football – Week 13 Betting Picks Against Spread

In week 12 of the college football season, I went 12-13 against the spread.

This week feels like a the calm before the storm. We have a few rivalry games this week, but those really start to ramp up next week. We just have a lot of teams finishing up their conference schedules.

Can Texas rebound after last week’s blowout loss against Georgia?

We at ‘America’s White Boy’ pick 25 college football games against the spread in Week 13 of the 2025-26 NCAA Football season (November 22nd, 2025).

Missouri Tigers at Oklahoma Sooners (-7.5) – My pick is Missouri Tigers +7.5

The Missouri Tigers (7-3, 5-4-1 ATS) are coming off a 49-27 home win over Mississippi State, which covered the -7 spread.

The Oklahoma Sooners (8-2, 5-4-1 ATS) are coming off a 23-21 road win over Alabama, which was a win against the +6.5 spread.

This betting line is bloated after Oklahoma upset Alabama last week. The Sooners haven’t been great at extending leads this year, so this will be tough to cover. Missouri RB Ahmad Hardy is coming off an unbelievable 300-yard rushing effort against MSU. I think Missouri’s defense will keep it close, so give me the points.

Syracuse Orange at Notre Dame Fighting Irish (-35.5) – My pick is Notre Dame Fighting Irish -35.5

The Syracuse Orange (3-7, 4-5-1 ATS) are coming off a bye week, and in their previous game, lost to Miami (FL) 38-10.

The Notre Dame Fighting Irish (8-2, 5-4-1 ATS) are coming off a 37-15 road win over Pitt, which covered the -13 spread.

This game would have been way more competitive before Syracuse (and former Irish) QB Steve Angeli suffered a season-ending injury. The Orange have been a disaster on offense ever since. Syracuse will have trouble putting up any points against the Irish. This line is large, but I think Notre Dame will cover at home.

Arkansas Razorbacks at Texas Longhorns (-9.5) – My pick is Arkansas Razorbacks +9.5

The Arkansas Razorbacks (2-8, 4-6 ATS) are coming off a 23-22 road loss to LSU, but was a win against the +4.5 spread.

The Texas Longhorns (7-3, 2-7-1 ATS) are coming off a 35-10 road loss to Georgia, and wasn’t close to the +3.5 betting line.

The Razorbacks have had a rough year, but the Longhorns is one of the worst betting teams in the country. I think this line is still too high, which is nuts considering how bad Texas looked against Georgia. Arkansas has a ton of issues, but they do have some positives with their ground game. If Arkansas QB Taylen Green can limit turnovers, they can compete against Texas. I’m taking the points in this game.

Kentucky Wildcats at Vanderbilt Commodores (-9.5) – My pick is Kentucky Wildcats +9.5

The Kentucky Wildcats (5-5, 5-5 ATS) are coming off a 42-10 home win over Tennessee Tech, and covered the -23.5 spread.

The Vanderbilt Commodores (8-2, 7-2-1 ATS) are coming off a 45-38 home win over Auburn, and covered the -6 spread.

Just a few weeks ago, Kentucky was a huge longshot to become bowl-elgible. They are now a win away after upset wins against Auburn and Florida. Their defense has taken a big step and they found finally their program quarterback in Cutter Boley. Vandy is having a great year, but their defense gives up too many plays. I think the Wildcats can keep this one close, so give me the points.

Duke Blue Devils at North Carolina Tar Heels (+6.5) – My pick is Duke Blue Devils -6.5

The Duke Blue Devils (5-5, 4-6 ATS) are coming off a 34-17 home loss to Virginia, and wasn’t close to the -5 betting line.

The North Carolina Tar Heels (4-6, 5-5 ATS) are coming off a 28-12 road loss to Wake Forest, and lost against the +3.5 spread.

After some nice wins in the middle of the year, Duke have lost three of their last four games. Their defense has given up at least 34 points in three-straight games. It was a difficult stretch, but they’ve been able to take care of business against the bad teams in the ACC. I would categorize the Tar Heels in that category. I think Duke will turn it around against their rival and cover on the road.

USC Trojans at Oregon Ducks (-9.5) – My pick is USC Trojans +9.5

The USC Trojans (8-2, 5-5 ATS) are coming off a 26-21 home win over Iowa, but failed to cover the -6.5 spread.

The Oregon Ducks (9-1, 5-4-1 ATS) are coming off a 42-13 home win over Minnesota, and covered the -27 spread.

I would put USC and Oregon on the same tier in the Big Ten. I think the Ducks are slightly better than the Trojans, but not by that much. I expect Oregon to win outright, but USC will keep it close, so give me the points.

Tennessee Volunteers at Florida Gators (+4) – My pick is Tennessee Volunteers -4

The Tennessee Volunteers (7-3, 3-6-1 ATS) are coming off a 42-9 home win over New Mexico State, but failed to cover the 42.5 spread.

The Florida Gators (3-7, 3-6-1 ATS) are coming off a 34-24 road loss to Ole Miss, and was a push against the betting line.

Tennessee can has beaten up on the mid-tier SEC teams this year. Their three losses were against Georgia, Alabama and Oklahoma. They haven’t been a good betting team due to their inability to stretch out big leads, due to their subpar defense. I think they have too much offense for the Gators to hang against. I’m taking Tennessee to cover on the road.

BYU Cougars at Cincinnati Bearcats (+2.5) – My pick is BYU Cougars -2.5

The BYU Cougars (9-1, 7-3 ATS) are coming off a 44-13 home win over TCU, which easily covered the -3 spread.

The Cincinnati Bearcats (7-3, 6-4 ATS) are coming off a 30-24 home loss to Arizona, and failed to cover the -6 spread.

BYU is clearly among the best dozen teams in the country. Their lone loss came against a buzzsaw Texas Tech offense. Cincinnati is a good team, but their schedule has been light. This betting line should be a point or two larger, so I’m jumping all over this. I’m taking BYU to cover on the road.

Kansas Jayhawks at Iowa State Cyclones (-4) – My pick is Iowa State Cyclones -4

The Kansas Jayhawks (5-5, 4-6 ATS) are coming off a bye week, and in their previous game, lost to Arizona 24-20.

The Iowa State Cyclones (6-4, 4-5-1 ATS) are coming off a bye week, and in their previous game, beat TCU 20-17.

This is battle between two inconsistent teams. Kansas had some great outings against good teams early this year, but their defense has completely collapsed. Iowa State had a similar trajectory, with QB Rocco Becht turning into a turnover machine. In defense of Becht, this happened against a stretch of difficult opponents. I think Becht will turn it around against a bad Kansas defense. I’m taking Iowa State to cover at home.

Connecticut Huskies at Florida Atlantic Owls (+7) – My pick is UConn Huskies -7

This is the section where we pick a smaller conference game.

The UConn Huskies (8-3, 6-3-2 ATS) are coming off a 26-16 home win over Air Force, and covered the -7.5 betting line.

The FAU Owls (4-6, 6-4 ATS) are coming off a 35-24 road loss to Tulane, but won against the +16 spread.

Connecticut has been a doormat for a long time. They’ve faced favorable betting lines just because bettors are so used to betting against them. They’ve beaten some notable programs, with wins against Duke and Boston College this year. FAU has a horrible defense, and I think this betting line still has value in it. This line should be closer to double digits, so I’m taking UConn to cover on the road.

QUICK HITS

Michigan State at Iowa (-16.5) – My pick is Iowa -16.5

TCU at Houston (-1) – My pick is Houston -1

Oklahoma State at UCF (-14) – My pick is UCF -14

Nebraska at Penn State (-8.5) – My pick is Nebraska +8.5

Pitt at Georgia Tech (-2.5) – My pick is Georgia Tech -2.5

Illinois at Wisconsin (+7.5) – My pick is Illinois -7.5

Arizona State at Colorado (+7.5) – My pick is ASU -7.5

Utah State at Fresno State (-2.5) – My pick is Fresno State -2.5

North Texas at Rice (+18) – My pick is North Texas -18

Hawaii at UNLV (-3) – My pick is Hawaii +3

BONUS PICKS!

New Mexico State at UTEP (-3) – My pick is UTEP -3

Liberty at Louisiana Tech (+1.5) – My pick is La Tech +1.5

Southern Miss at South Alabama (+1.5) – My pick is South Alabama +1.5

Louisiana-Monroe at Texas State (-17.5) – My pick is Texas State -17.5

Washington State at James Madison (-14) – My pick is JMU -13.5

Sweetbob’s college football picks against the spread record in previous seasons:

2013: 134-79-8
2014: 148-118-4
2015: 149-118-3
2016: 196-145-6
2017: 183-159-13
2018: 177-157-6
2019: 187-141-8
2020: 170-160-5
2021: 167-151-8
2022: 185-150-5
2023: 155-144-10
2024: 183-164-11
2025: 163-134-3

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sweetbob-author-picAbout the Author…

Bobby Roberts (otherwise known as Sweetbob) is the creator of ‘America’s White Boy’ and contributor at Project Shanks. His writing has been featured on ESPN’s ‘SportsNation’, Sports Illustrated’s Hot Clicks, Guyspeed, and various other sites. You can follow him on X at @Sweetbob

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